Cleveland NORML

Medical Marijuana: Clearing the Smoke

Mar 04, 2011 -

A wonderfull piece examining the issue of medical marijuana from a scientific perspective.

Watch the full episode. See more MontanaPBS Presents.

Another Patient Helped By Marijuana

Mar 02, 2011 -

Jacqueline suffers from Cerebral Palsy, as a result of this she has a severe stutter and has trouble using her right arm. The positive effect marijuana has on her is nothing short of amazing.

Crohn's Disease Survivor Shona Banda Tells How Medical Marijuana Oil Helps Her "Live Free"

Feb 20, 2011 -

Medical Marijuana Stops Spread of Breast Cancer - NBC NEWS

Jan 29, 2011 -

San Francisco
Medical Marijuana Stops Spread of Breast Cancer - NBC NEWS
Marianne Favro/KNTV
Reporting
EXCERPTED FROM PUBMED:
Cannabidiol enhances the inhibitory effects of Delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival:

The cannabinoid 1 (CB(1)) and cannabinoid 2 (CB(2)) receptor agonist Delta(9)-tetrahydrocannabinol (THC) has been shown to be a broad-range inhibitor of cancer in culture and in vivo, and is currently being used in a clinical trial for the treatment of glioblastoma. It has been suggested that other plant-derived cannabinoids, which do not interact efficiently with CB(1) and CB(2) receptors, can modulate the actions of Delta(9)-THC. There are conflicting reports, however, as to what extent other cannabinoids can modulate Delta(9)-THC activity, and most importantly, it is not clear whether other cannabinoid compounds can either potentiate or inhibit the actions of Delta(9)-THC. We therefore tested cannabidiol, the second most abundant plant-derived cannabinoid, in combination with Delta(9)-THC. In the U251 and SF126 glioblastoma cell lines, Delta(9)-THC and cannabidiol acted synergistically to inhibit cell proliferation. The treatment of glioblastoma cells with both compounds led to significant modulations of the cell cycle and induction of reactive oxygen species and apoptosis as well as specific modulations of extracellular signal-regulated kinase and caspase activities. These specific changes were not observed with either compound individually, indicating that the signal transduction pathways affected by the combination treatment were unique. Our results suggest that the addition of cannabidiol to Delta(9)-THC may improve the overall effectiveness of Delta(9)-THC in the treatment of glioblastoma in cancer patients.

PMID: 20053780